Sexual Dysfunction May be a Cause for Heart Disease in Diabetic Men

Yes this truth has unveiled in the 72th American Diabetes Association. Scientists have stated that sexual dysfunction plays a key role for heart diseases in people having type 1 diabetes.

Sara Turek, MPH, and colleagues examined the association of sexual dysfunction with clinical markers of vascular disease in 301 men from the on-going 50-Year Medallist Study who have had type 1 diabetes for more than 50 years. Turek is a coordinator for the study, which is being conducted at the Joslin Diabetes Centre in Boston.
In prior analyses, only about half of the Medallist population has been shown to develop diabetic nephropathy, retinopathy, and neuropathy, which are complications that occur in nearly all type 1 diabetic patients in the general population by about 30 years after their initial diagnosis. The rate of cardiovascular disease in Medallists, however, is similar to that reported in age-matched patients with type 2 diabetes.
Research has also demonstrated that participants in the Medallist Study have usually maintained good long-term glycaemic control.
One issue that had not been addressed in the Medallist cohort was sexual dysfunction. "We have noticed that while sexual dysfunction is a common complaint among male Medallists that significantly impairs their quality of life, there is a paucity of data on sexual dysfunction in men with long-duration type 1 diabetes," Turek commented.
Overall, 210 male Medallists, or 69.8%, had sexual dysfunction as determined by an affirmative response to the question: "Have you ever had sexual problems?"
Males reporting a positive response had a haemoglobin (Hb)A1c of 7.1± 0.9% versus 6.8 ±0.8% in the no-dysfunction cohort (P=0.02). Body mass index (BMI) was 26.1 ±3.8 kg/m2 and. 25.8 ±3.6 kg/m2 (P=0.03) in the two groups, respectively, total cholesterol was 159.3 ±32.1 and 150.1 ±30.6 mg/dL(P=0.02), and high-density lipoprotein (HDL) was 55.1 ±16.2 and 62.1 ±17.8 mg/dL (P<0.01).
In addition, a history of cigarette smoking was associated with prevalence of sexual dysfunction (51.7% versus 39.3% in the sexual dysfunction and non-sexual dysfunction groups, respectively, P=0.05).
The researchers also examined clinical inflammatory markers that are commonly associated with cardiovascular risk and disease including C-reactive protein (CRP), interleukin (IL-6), and plasminogen activator inhibitor type 1 (PAI-1). Only IL-6 was significantly associated with patient reports of sexual dysfunction (P=0.03), and the association was independent of BMI, age, and glycemic control.
The findings suggest that sexual dysfunction follows the pattern of macrovascular complications seen in the Medalist group, Turek said. Also, the association with Il-6 may provide a pathway linking sexual dysfunction and macrovascular complications in this cohort.
Sara Turek said:

"The clinical message is that sexual dysfunction might be a more overt sign of cardiovascular issues or future cardiovascular issues than other clinical markers of cardiovascular disease symptoms such as hypertension, high cholesterol, andatherosclerosis. So if a patient presents with a complaint of sexual dysfunction, the physician may want to screen for cardiovascular problems since erectile dysfunctionmay be a predictor of increased cardiometabolic risk in aging men."

Stephanie Hastings, BA, also a coordinator for the Medalist Study, emphasized that while the determination of erectile dysfunction based on a single question is a limitation to the study, she is confident that the measure provided an accurate assessment of the presence of erectile dysfunction in this group. "Sure, it's subjective and open to interpretation but we spend a lot of time with our patients, and we find that they are very willing to share whatever information we request in order to help us in our research. We plan to follow up with a lengthier questionnaire, which we expect the majority of the participants to complete openly and honestly," she said.

Tags: Diabetes , Heart , Sexual Health